Heteroaryl derivatives and their use as medicaments

ABSTRACT

The invention relates to novel quinoline derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

FIELD OF THE INVENTION

The invention relates to novel heteroaryl derivatives of the formula 1, to their preparation and to their use as medicaments, in particular for treating tumors.

DESCRIPTION OF THE INVENTION

According to one aspect of the invention, novel quinoline derivatives of the formula 1

in which

-   -   R, R₁, R₂, R₃ can be attached to any of the quinoline carbon         atoms C₂ to C₈, are the same or different and independently of         one another denote hydrogen, straight-chain or branched         (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, straight-chain or branched         (C₁-C₈)-alkylcarbonyl, preferably acetyl, straight-chain or         branched (C₁-C₈)-alkoxy, halogen, aryl-(C₁-C₈)-alkoxy,         preferably benzyloxy or phenylethyloxy, nitro, amino,         mono-(C₁-C₄)-alkylamino, di-(C₁-C₄)-alkylamino,         (C₁-C₈)-alkoxycarbonylamino,         (C₁-C₆)-alkoxycarbonylamino-(C₁-C₈)-alkyl, cyano, straight-chain         or branched cyano-(C₁-C₆)-alkyl, carboxyl,         (C₁-C₈)-alkoxycarbonyl, (C₁-C₄)-alkyl which is substituted by         one or more fluorine atoms, preferably the trifluoromethyl         group, carboxy-(C₁-C₈)-alkyl or         (C₁-C₈)-alkoxycarbonyl-(C₁-C₆)-alkyl, (C₂-C₆)-alkenyl,         preferably allyl, (C₂-C₆)-alkynyl, preferably ethynyl or         propargyl, straight-chain or branched cyano-(C₁-C₆)-alkyl,         preferably cyanomethyl, aryl, where the aryl radical can be         unsubstituted or mono- or polysubstituted by the same or         different substituents from the group of halogen, straight-chain         or branched (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, carboxyl,         straight-chain or branched (C₁-C₈)-alkoxycarbonyl, preferably         tert-butoxycarbonyl, by trifluoromethyl, hydroxyl,         straight-chain or branched (C₁-C₈)-alkoxy, preferably methoxy or         ethoxy, benzyloxy, nitro, amino, mono-(C₁-C₄)-alkylamino,         di-(C₁-C₄)-alkylamino, cyano, straight-chain or branched         cyano-(C₁-C₆)-alkyl, where additionally R and R₁ or R₂ and R₃         may form a fused aromatic 6-membered ring with the quinoline         ring forming an acridine ring which for its part can be         substituted at any C atom ring position by the radicals R, R₁,         R₂ and R3 having the meanings mentioned above;     -   Z is oxygen or sulfur, where the radical     -    substituted on the quinoline heterocycle can be attached to C         atoms C₂-C₈ of the quinoline ring skeleton;     -   P, Q independently of one another represent oxygen or in each         case two hydrogen atoms (i.e. —CH₂—);     -   X is nitrogen or C—R₅, where R₅ represents hydrogen or         (C₁-C₆)alkyl;     -   n,m independently of one another denotes an integer between 0-3,         with the proviso that in the case n=0, X denotes a CR₅R₆ group         where R₅ and R₆ independently of one another represent hydrogen         or (C₁-C₆)-alkyl and that the nitrogen atom adjacent to the C═Z         group is substituted by a hydrogen atom or a (C-C₆)-alkyl group;     -   R₄ or a straight-chain or branched (C₁-C₂₀)-alkyl radical which         can be saturated or unsaturated, with one to three double and/or         triple bonds, and which can be unsubstituted or may optionally         be substituted at the same or different C atoms by one, two or         more aryl, heteroaryl, halogen, cyano,         (C₁-C₆)-alkoxycarbonylamino, (C₁-C₆)-alkoxy, amino,         mono-(C₁-C₄)-alkylamino or di-(C₁-C₄)-alkylamino; a         (C₆-C₁₄)-aryl radical, (C₆-C₁₄)-aryl-(C₁-C₄)-alkyl radical, or a         a (C₂-C₁₀)-heteroaryl or (C₂-C₁₀)-heteroaryl-(C₁-C₄)-alkyl         radical which contains one or more heteroatoms selected from the         group of N, O and S, where the (C₁-C₄)-alkyl radical can be         unsubstituted or mono- or polysubstituted by the same or         different substituents from the group of (C₁-C₆)-alkyl, halogen         or oxo (═O), and where the (C₆-C₁₄)-aryl or (C₂-C₁₀)-heteroaryl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of straight-chain         or branched (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, halogen, cyano,         (C₁-C₆)-alkoxycarbonylamino, (C₁-C₆)-alkoxy, carboxyl,         (C₁-C₈)-alkoxycarbonyl, straight-chain or branched (C₁-C₆)-alkyl         which is substituted by one or more fluorine atoms, preferably         trifluoromethyl, hydroxyl, straight-chain or branched         (C₁-C₈)-alkoxy, preferably methoxy or ethoxy, where adjacent         oxygen atoms may also be linked by (C₁-C₂)-alkylene groups,         preferably by a methylene group, benzyloxy, nitro, amino,         mono-(C₁-C₄)-alkylamino, di-(C₁-C₄)-alkylamino, aryl, which for         its part can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of straight-chain         or branched (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, carboxyl,         straight-chain or branched (C₁-C₈)-alkoxycarbonyl, by         trifluoromethyl, hydroxyl, straight-chain or branched         (C₁-C₈)-alkoxy, preferably methoxy or ethoxy, benzyloxy, nitro,         amino, mono-(C₁-C₄)-alkylamino, di-(C₁-C₄)-alkylamino, cyano,         straight-chain or branched cyano-(C₁-C₆)-alkyl;     -   and their structural isomers and stereoisomers, in particular         tautomers, diastereomers and enantiomers, and their         pharmaceutically acceptable salts, in particular acid addition         salts, are provided.

Thus, for example, the compounds of the formula (1) according to the invention which have one or more centers of chirality and which are present as racemates can be separated by methods known per se into their optical isomers, i.e. enantiomers or diastereomers. The separation can be carried out by column separation on chiral phases or by recrystallization from an optically active solvent or using an optically active acid or base or by derivatization with an optically active reagent, such as, for example, an optically active alcohol, and subsequent removal of the radical.

Furthermore, the quinoline derivatives of the formula (1) according to the invention can be converted into their salts with inorganic or organic acids, in particular, for pharmaceutical use, into their physiologically acceptable salts. Acids which are suitable for this purpose are, for example, hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, fumaric acid, succinic acid, lactic acid, citric acid, acetic acid, tartaric acid, malic acid, embonic acid, malonic acid, trifluoroacetic acid or maleic acid.

Moreover, the compounds of the formula (1) according to the invention can, if they contain a sufficiently acidic group, such as a carboxyl group, be converted, if desired, into their salts with inorganic or organic bases, in particular, for pharmaceutical use, into their physiologically acceptable salts. Bases which are suitable for this purpose are, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, lysine, cyclohexylamine, ethanolamine, diethanolamine and triethanolamine.

According to a preferred embodiment, quinoline derivatives of the formula 1 are provided in which R, R1, R2, R3, X, Z, P, Q, n and m have the meanings given above and

-   -   R₄ denotes a straight-chain or branched (C₁-C₂₀)-alkyl radical         which can be saturated or unsaturated, with one to three double         and/or triple bonds, and which can be unsubstituted or         optionally substituted on the same or different C atoms by one,         two or more aryl, heteroaryl, halogen, (C1-C6)-alkoxy, amino,         mono-(C₁-C₄)-alkylamino or di-(C₁-C₄)-alkylamino;     -   a phenyl ring or a naphthyl ring, each of which can be         unsubstituted or mono- or polysubstituted by the same or         different substituents from the group of straight-chain or         branched (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, halogen, carboxyl,         (C₁-C₈)-alkoxycarbonyl, straight-chain or branched (C₁-C₆)-alkyl         which is substituted by one or more fluorine atoms, preferably         trifluoromethyl, hydroxyl, straight-chain or branched         (C₁-C₈)-alkoxy, preferably methoxy or ethoxy, where adjacent         oxygen atoms may also be linked by (C₁-C₂)-alkylene groups,         preferably a methylene group, benzyloxy, nitro, amino,         mono-(C₁-C₄)-alkylamino, di-(C₁-C₄)-alkylamino, aryl, which for         its part can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of straight-chain         or branched (C₁-C₈)-alkyl, (C₃-C₇)-cycloalkyl, carboxyl,         straight-chain or branched (C₁-C₈)-alkoxycarbonyl, by         trifluoromethyl, hydroxyl, straight-chain or branched         (C₁-C₈)-alkoxy, preferably methoxy or ethoxy, benzyloxy, nitro,         amino, mono-(C₁-C₄)-alkylamino, di-(C₁-C₄)-alkylamino, cyano,         straight-chain or branched cyano-(C₁-C₆)-alkyl;     -   a 2-, 4-, 5- or 6-pyrimidinyl radical, or a 2-, 4-, 5- or         6-pyrimidinyl-(C₁-C₄)-alkyl radical, where the (C₁-C₄)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2-, 4-, 5- or 6-pyrimidinyl radical         can be unsubstituted or mono- to trisubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 3-, 4-, 5- or 6-pyridazinyl radical, or a 3-, 4-, 5- or         6-pyridazinyl-(C₁-C₄)-alkyl radical, where the (C₁-C₄)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 3-, 4-, 5- or 6-pyridazinyl radical         can be unsubstituted or mono- to trisubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 3-, 5- or 6-pyrazinyl radical, or a 2-, 3-, 5- or         6-pyrazinyl-(C₁-C₄)-alkyl radical, where the (C₁-C₄)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2-, 3-, 5- or 6-pyrazinyl radical         can be unsubstituted or mono- to trisubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 3-, 4-, 5-, 6-, 7-, or 8-cinnolinyl radical, or a 3-, 4-, 5-,         6-, 7-, or 8-cinnolinyl-(C₁-C₄)-alkyl radical, where the         (C₁-C₄)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 3-, 4-, 5-,         6-, 7-, or 8-cinnolinyl radical can be unsubstituted or mono- to         pentasubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 4-, 5-, 6-, 7-, or 8-quinazolinyl radical, or a 2-, 4-,         5-, 6-, 7-, or 8-quinazolinyl-(C₁-C₄)-alkyl radical, where the         (C₁-C₄)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen or oxo (═O), and the         or [sic] 2-, 4-, 5-, 6-, 7-, or 8-quinazolinyl radical can be         unsubstituted or mono- to pentasubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 3-, 5-, 6-, 7-, or 8-quinoxalinyl radical, or a 2-, 3-,         5-, 6-, 7-, or 8-quinoxalinyl-(C₁-C₄)-alkyl radical, where the         (C₁-C₄)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the or [sic]         2-, 3-, 5-, 6-, 7-, or 8-quinoxalinyl radical can be         unsubstituted or mono- to pentasubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 4-, 5-, 6-, 7-, or 8-phthalazinyl radical, or a 1-, 4-,         5-, 6-, 7-, or 8-phthalazinyl-(C₁-C₄)-alkyl radical, where the         (C₁-C₄)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the or [sic]         1-, 4-, 5-, 6-, 7-, or 8-phthalazinyl radical can be         unsubstituted or mono- to pentasubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolyl radical, or a 2-, 3-, 4-,         5-, 6-, 7 or 8-quinolyl-(C₁-C₄)-alkyl radical, where the         (C₁-C₄)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 2-, 3-, 4-,         5-, 6-, 7- or 8-quinolyl radical can be unsubstituted or mono-         to hexasubstituted by the same or different substituents from         the group of hydrogen, (C₁-C₆)-alkyl, preferably methyl,         particularly preferably 2-methyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolyl radical, or a 1-, 3-,         4-, 5-, 6-, 7- or 8-isoquinolyl-(C₁-C₄)-alkyl radical, where the         (C₁-C₄)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 1-, 3-, 4-,         5-, 6-, 7- or 8-isoquinolyl radical can be unsubstituted or         mono- to hexasubstituted by the same or different substituents         from the group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro,         amino, mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 6-, 8- or 9-[9H]-purinyl radical, or a 2-, 6-, 8- or         9-[9H]-purinyl-(C₁-C₄)-alkyl radical, where the (C₁-C₄)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2-, 6-, 8- or 9-[9H]-purinyl         radical can be unsubstituted or mono- to trisubstituted by the         same or different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 6-, 7- or 8-[7H]-purinyl radical, or a 2-, 6-, 7- or         8-[7H]-purinyl-(C₁-C₄)-alkyl radical, where the (C₁-C₄)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2-, 6-, 7- or 8-[7H]-purinyl         radical can be unsubstituted or mono- to trisubstituted by the         same or different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridinyl radical, or a         1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridinyl-(C₁-C₄)-alkyl         radical, where the (C₁-C6)-alkyl radical can be unsubstituted or         mono- or polysubstituted by the same or different substituents         from the group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the         1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridinyl radical can be         unsubstituted or mono- to octasubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-phenanthridinyl radical,         or a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or         9-phenanthridinyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen or oxo (═O), and the 1-, 2-, 3-, 4-, 5-,         6-, 7-, 8- or 9-phenanthridinyl radical can be unsubstituted or         mono- to octasubstituted by the same or different substituents         from the group of (C₁-C6)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, (C₆-C₁₀)-aryl-(C₁-C₆)-alkoxy, preferably         benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 3-, 4-, 5- or 6-pyridyl radical where the 2-, 3-, 4-, 5-         or 6-pyridyl radical can be unsubstituted or mono- to         tetrasubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 3-, 4-, 5- or 6-pyridinyl-(C₁-C₆)-alkyl radical, where the         (C₁-C₆)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 2-, 3-, 4-,         5- or 6-pyridinyl radical can be unsubstituted or mono- to         tetrasubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 3-, 4- or 5-thienyl radical, or a 2-, 3-, 4- or         5-thienyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl radical         can be unsubstituted or mono- or polysubstituted by the same or         different substituents from the group of (C₁-C₆)-alkyl, halogen         or oxo (═O), and the 2-, 3-, 4- or 5-thienyl radical can be         unsubstituted or mono- to trisubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 4-, or 5-thiazolyl radical, or a 2-, 4-, or         5-thiazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2-, 4-, or 5-thiazolyl radical can         be unsubstituted or mono- or disubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 3-, 4-, or 5-isothiazolyl radical, or a 3-, 4-, or         5-isothiazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 3-, 4-, or 5-isothiazolyl radical         can be unsubstituted or mono- or disubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 4-, 5-, 6-, or 7-benzothiazolyl radical, or a 2-, 4-, 5-,         6-, or 7-benzothiazolyl-(C₁-C₆)-alkyl radical, where the         (C₁-C₆)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 2-, 4-, 5-,         6-, or 7-benzothiazolyl radical can be unsubstituted or mono- to         tetrasubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 2-, 4-, or 5-imidazolyl radical, or a 1-, 2-, 4-, or         5-imidazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 1-, 2-, 4-, or 5-imidazolyl radical         can be unsubstituted or mono- to trisubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 3-, 4-, or 5-pyrazolyl radical, or a 1-, 3-, 4- or         5-pyrazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 1-, 3-, 4- or 5-pyrazolyl radical         can be unsubstituted or mono- to trisubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 2-, 3-, 4-, or 5-pyrrolyl radical, or a 1-, 2-, 3-, 4-, or         5-pyrrolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 1-, 2-, 3-, 4- or 5-pyrrolyl         radical can be unsubstituted or mono- to tetrasubstituted by the         same or different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 3-, or 5-[1.2.4]-triazolyl radical, or a 1-, 3-, or         5-[1.2.4]-triazolyl-(C₁-C₆)-alkyl radical, where the         (C₁-C₆)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen or oxo (═O), and the         1-, 3-, or 5-[1.2.4]-triazolyl radical can be unsubstituted or         mono- or disubstituted by the same or different substituents         from the group of (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 4-, or 5-[1.2.3]-triazolyl radical, or a 1-, 4-, or         5-[1.2.3]-triazolyl-(C₁-C₆)-alkyl radical, where the         (C₁-C₆)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 1-, 4-, or         5-[1.2.3]-triazolyl radical can be unsubstituted or mono- or         disubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1- or 5-[1H]-tetrazolyl radical, or a 1-, or         5-[1H]-tetrazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 1-, or 5-[1H]-tetrazolyl radical         can be unsubstituted or substituted by hydrogen, (C₁-C₆)-alkyl,         halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2- or 5-[2H]-tetrazoyl radical, or a 2- or         5-[2H]-tetrazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2- or 5-[2H]-tetrazolyl radical can         be unsubstituted or substituted by hydrogen, (C₁-C₆)-alkyl,         halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 4-, or 6-[1.3.5]-triazinyl radical, or a 2-, 4-, or         6-[1.3.5]-triazinyl-(C₁-C₆)-alkyl radical, where the         (C₁-C₆)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen or oxo (═O), and the         2-, 4-, or 6-[1.3.5]-triazinyl radical can be unsubstituted or         mono- or disubstituted by the same or different substituents         from the group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro,         amino, mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁-C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 2-, 4-, or 5-oxazolyl radical, or a 2-, 4-, or         5-oxazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 2-, 4-, or 5-oxazolyl radical can         be unsubstituted or mono- or disubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 3-, 4-, or 5-isoxazolyl radical, or a 3-, 4-, or         5-isoxazolyl-(C₁-C₆)-alkyl radical, where the (C₁-C₆)-alkyl         radical can be unsubstituted or mono- or polysubstituted by the         same or different substituents from the group of (C₁-C₆)-alkyl,         halogen or oxo (═O), and the 3-, 4-, or 5-isoxazolyl radical can         be unsubstituted or mono- or disubstituted by the same or         different substituents from the group of hydrogen,         (C₁-C₆)-alkyl, halogen, nitro, amino, mono-(C₁-C₆)-alkylamino,         di-(C₁-C₆)-alkylamino, hydroxyl, (C₁-C₆)-alkoxy, benzyloxy,         carboxyl, (C₁-C₆)-alkoxycarbonyl, (C₁-C₆)-alkoxycarbonylamino or         (C₁-C₆)-alkyl which is mono- or polysubstituted by fluorine,         preferably trifluoromethyl, (C₆-C₁₀)-aryl and         (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl;     -   a 1-, 2-, 3-, 4-, 5-, 6- or 7-indolyl radical, or a 1-, 2-, 3-,         4-, 5-,6- or 7-indolyl-(C₁-C₆)-alkyl radical, where the         (C₁-C₆)-alkyl radical can be unsubstituted or mono- or         polysubstituted by the same or different substituents from the         group of (C₁-C₆)-alkyl, halogen or oxo (═O), and the 1-, 2-, 3-,         4-, 5-, 6- or 7-indolyl radical can be unsubstituted or mono- to         hexasubstituted by the same or different substituents from the         group of hydrogen, (C₁-C₆)-alkyl, halogen, nitro, amino,         mono-(C₁-C₆)-alkylamino, di-(C₁-C₆)-alkylamino, hydroxyl,         (C₁-C₆)-alkoxy, benzyloxy, carboxyl, (C₁-C₆)-alkoxycarbonyl,         (C₁-C₆)-alkoxycarbonylamino or (C₁ -C₆)-alkyl which is mono- or         polysubstituted by fluorine, preferably trifluoromethyl,         (C₆-C₁₀)-aryl and (C₆-C₁₀)-aryl-(C₁-C₆)-alkyl and the isomers,         in particular tautomers, diastereomers and enantiomers, and the         pharmaceutically acceptable salts, in particular acid addition         salts, thereof.

According to a further embodiment, quinoline derivatives of the formula (1) are provided which are characterized in that R, R₁, R₂, R₃, X, Z, P, Q, n and m have the meanings given above and R₄ represents phenyl which is unsubstituted or substituted by one to five the same or different (C₁-C₆)-alkoxy groups, where adjacent oxygen atoms may also be linked by (C₁-C₂)-alkylene groups.

According to a further embodiment, quinoline derivatives of the formula (1) are provided which are characterized in that R, R₁, R₂, R₃, X, Z, P, Q, n and m have the meanings given above and R₄ represents 3,5-dimethoxyphenyl.

According to a further embodiment, quinoline derivatives of the formula (1) are provided which are characterized in that R₄ has the meanings given above, R, R₁, R₂, R₃ each represent a hydrogen atom, Z represents an oxygen atom and X represents a nitrogen atom, P and Q each represent two hydrogen atoms (i.e. —CH2—), m is zero and n is the integer 2.

According to a further embodiment, quinoline derivatives of the formula (1) are provided which are characterized in that R, R₁, R₂, R₃ each represent a hydrogen atom, Z represents an oxygen atom, X represents a nitrogen atom, P and Q each represent two hydrogen atoms (i.e. —CH2—), m is zero, n represents the integer 2 and R₄ represents a 3,5-dimethoxyphenyl radical.

According to a further aspect of the invention, a process for preparing quinoline derivatives of the formula (1) is provided which is characterized in that a quinoline carboxylic acid of the formula (2)

in which R, R1, R2, R3 have the meanings given above, Z denotes an oxygen or sulfur atom and Y represents a leaving group such as halogen, hydroxyl, (C1-C6)-alkoxy, preferably methoxy or ethoxy, —O-tosyl, —O—mesyl or imidazolyl, is reacted with an amine of the formula (3)

in which R4, X, P, Q, m and n are as defined above, using, if appropriate, diluents and auxiliaries, and the desired quinoline derivatives are formed. Synthesis Route

The compounds of the formula 1 can be obtained according to Scheme 1 below:

The starting materials (2) and (3) are either commercially available or can be prepared by procedures known per se. The starting materials (2) and (3) are useful intermediates for preparing the quinoline derivatives of the formula (1) according to the invention.

The solvents and auxiliaries to be used, if appropriate, and the reaction parameters to be used, such as reaction temperature and reaction time, are known to the person skilled in the art owing to his expert knowledge.

The quinoline derivatives of the formula (1) according to the invention are suitable as medicaments, in particular as antitumor agents, for treating mammals, in particular man, but also domestic animals such as horses, cattle, dogs, cats, hares, sheep, poultry and the like.

According to a further aspect of the invention, a method for controlling tumors in mammals, in particular man, is provided which is characterized in that at least one quinoline derivative of the formula (1) is administered to a mammal in an amount effective for the treatment of the tumor. The therapeutically effective dose of the quinoline derivative according to the invention in question which is to be administered for the treatment depends inter alia on the nature and the stage of the oncosis, the age and the sex of the patient, the type of administration and the duration of the treatment. Administration can take place orally, rectally, buccally (for example sublingually), parenterally (for example subcutaneously, intramuscularly, intradermally or intravenously), topically or transdermally.

According to a further aspect of the invention, medicaments for the treatment of tumors are provided which are characterized in that they comprise, as active ingredient, at least one quinoline derivative according to any of claims 1 to 4 or a pharmaceutically acceptable salt thereof, if appropriate together with customary pharmaceutically acceptable auxiliaries, additives and carriers. These can be solid, semisolid, liquid or aerosol preparations. Suitable solid preparations are, for example, capsules, powders, granules, tablets. Suitable semisolid preparations are, for example, ointments, creams, gels, pastes, suspensions, oil-in-water and water-in-oil emulsions. Suitable liquid preparations are, for example, sterile aqueous preparations for parenteral administration which are isotonic with the blood of the patient.

The invention is to be illustrated in more detail by the example below, without being restricted to the example.

1-(3,5-dimethoxyphenyl)-4-(4-quinolyl-carbonyl)piperazine

2 g (11.5 mmol) of quinoline-4-carboxylic acid were suspended in 80 ml of DMF. With stirring, 1.74 g (17.2 mmol) of N-methylmorpholine and then a solution of 8.95 g (17.2 mmol) of Py-BOP (1-benzotriazolyltripyrrolidinophosphonium hexafluorophosphate) and 2.56 g (11.5 mmol) of 1-(3,5-dimethoxyphenyl)piperazine in 25 ml of DMF were added to this mixture. The mixture was stirred at RT for 12 h, the DMF was distilled off under reduced pressure and the residue was purified on a silica gel column (Kieselgel 60, from Merck AG, Darmstadt) using the mobile phase dichloromethane/methanol/25 percent ammonia (90:10:1 v/v/v).

Yield: 3.4 g (78.3% of theory) m.p.: 146-148° C.

TABLE 8 New Chinolyl-Derivatives with antitumoral activity m/e Ex. R R₁ R₂ R₃ X Z n m P Q R₄ Code-Nr. (M + H) 1 H H H H N O 2 0 H₂ H₂ 24203 378 2 H H H H N O 2 0 H₂ H₂ 43589 378 HCl- Salz 3 2-(4-chloro = H 6-CH₃ 7-Cl N O 2 0 H₂ H₂ 68780 537 phenyl) 4 2-CH₃ 3-OH H H N O 2 0 H₂ H₂ 68675 408 5 2-(3.4-dimeth = H H 7-CH₃ N O 2 0 H₂ H₂ 68823 528 oxyphenyl) 

1. Quinoline derivatives according to the formula 1

in which R, R₁, R₂, R₃ can be attached to any of the quinoline carbon atoms C₂ to C₈, are identical or different and independently of one another denote hydrogen, straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, straight-chain or branched C₁₋₈ alkylcarbonyl, straight-chain or branched C₁₋₈alkoxy, halogen, aryl-C₁₋₈ alkoxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, C₁₋₈ alkoxycarbonylamino, C₁₋₆ alkoxycarbonylamino-C₁₋₈ alkyl, cyano, straight-chain or branched cyano-(C₁-C₆)-alkyl, carboxyl, C₁₋₈, alkoxycarbonyl, C₁₋₄ alkyl which is substituted by one or more fluorine atoms, carboxy-C₁₋₈ alkyl or C₁₋₈ alkoxycarbonyl-C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, straight-chain or branched cyano-C₁₋₆ alkyl, aryl, where the aryl radical can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of halogen, straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, carboxyl, straight-chain or branched C₁₋₈ alkoxycarbonyl, by trifluoromethyl, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, benzyloxy, intro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, cyano, straight-chain or branched cyano-C₁₋₆ alkyl, where R and R₁ or R₂ and R₃ can form a fused aromatic 6-membered ring with the quinoline ring forming an acridine ring which for its part can be substituted at any C atom ring position by the radicals R, R₁, R₂ and R₃ having the meanings mentioned above; P and Q are each 2 hydrogen atoms; Z is oxygen or sulfur, where the radical

substituted on the quinoline heterocycle can be attached to C atoms C₂₋₈ of the quinoline ring skeleton; X is nitrogen n is 1 or 2 and m is 0 or 1, with the proviso that the sum of n and m is 2; R₄ is a straight-chain or branched C₁₋₂₀ alkyl radical which can be saturated or unsaturated, with one to three double and/or triple bonds, and which can be unsubstituted or can optionally be substituted at the same or different C atoms by one, two or more aryl, heteroaryl, halogen, cyano, C₁₋₆ alkoxycarbonylamino, C₁₋₆ alkoxy, amino, mono-C₁₋₄ alkylamino or di-C₁₋₄ alkylamino; a C₆₋₁₄ aryl radical, or a C₂₋₁₀ heteroaryl or C₂₋₁₀ heteroaryl-C₁₋₄ alkyl radical which contains one or more heteroatoms selected from the group consisting of N, O and S, where the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of C₁₋₆ alkyl, halogen or oxo (═O) and where the C₆₋₁₄ aryl or C₂₋₁₀ heteroaryl radical can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, halogen, cyano, C₁₋₆ alkoxycarbonylamino, C₁₋₆ alkoxy, carboxyl, C₁₋₈, alkoxycarbonyl, straight-chain or branched C₁₋₆ alkyl which is substituted by one or more fluorine atoms, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, where adjacent oxygen atoms can also be linked by C₁₋₂ alkylene groups, benzyloxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, aryl, which can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, carboxyl, straight-chain or branched C₁₋₈ alkoxycarbonyl, trifluoromethyl, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, benzyloxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, cyano, straight-chain or branched cyano-C₁₋₆ alkyl; and their structural isomers and stereoisomers and their pharmaceutically acceptable salts.
 2. The quinoline derivative of formula 1 of claim 1, wherein R, R₁, R₂, R₃, X, Z, P, Q, n and m have the meanings given in claim 1; R₄ is a straight-chain or branched C₁₋₂₀ alkyl radical which can be saturated or unsaturated, with one to three double and/or triple bonds, and which can be unsubstituted or optionally substituted on the same on different C atoms by one, two or more aryl, heteroaryl, halogen, C₁₋₆ alkoxy, amino, mono- C₁₋₄ alkylamino or di-C₁₋₄ alkylamino; a phenyl ring or a naphthyl ring, each of which can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, halogen, cyano, C₁₋₆ alkoxycarbonylamino, C₁₋₆ alkoxy, carboxyl, C₁₋₆ alkoxycarbonyl, straight-chain or branched C₁₋₆ alkyl which is substituted by one or more fluorine atoms, hydroxyl, straightchain or branched C₁₋₆ alkoxy, benzyloxy, nitro, amino, mono- C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, aryl, which can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, carboxyl, straight-chain or branched C₁₋₈ alkoxycarbonyl, by trifluoromethyl, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, benzyloxy, nitro, amino, mono-C₁₋₄ alkylamino di-C_(c1-4) alkylamino, cyano, straight-chain or branched cyano- C₁₋₆ alkyl.
 3. The quinoline derivative of claim 1, wherein R, R₁, R₂, R₃, X, Z, P, Q, n and m have the meanings given above, and R₄ is phenyl which is unsubstituted or substituted by one to five to seine or different C₁₋₆ alkoxy groups, where adjacent oxygen atoms can also be linked by C₁₋₂ alkylene groups.
 4. The quinoline derivative of claim 1, wherein R, R₁, R₂, R₃, X, Z, P, Q n and m have the meanings given above and R₄ is 3,5-dimethoxyphenyl.
 5. The quinoline derivative of claim 1, wherein R, R₁, R₂, R₃ are each a hydrogen atom, Z is an oxygen atom, X is a nitrogen atom, P and Q each are two hydrogen atoms as in —CH₂—, m is zero, n is 2, and R₄ is a 3,5-dimethoxyphenyl radical.
 6. Quinoline derivatives according to the formula 1

in which R, R₁, R₂, R₃ can be attached to any of the quinoline carbon atoms C₂ to C₈, are identical or different and independently of one another denote hydrogen, straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, straight-chain or branched C₁₋₈ alkylcarbonyl, straight-chain or branched C₁₋₈ alkoxy, halogen, aryl-C₁₋₈ alkoxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, C₁₋₄ alkoxycarbonylamino, C₁₋₆ alkoxycarbonylamino-C₁₋₈ alkyl, cyano, straight-chain or branched cyano-(C₁-C₆)-alkyl, carboxyl, C₁₋₈ alkoxycarbonyl, C₁₋₄ alkyl which is substituted by one or more fluorine atoms, carboxy-C₁₋₈ alkyl or C₁₋₈ alkoxycarbonyl-C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, straight-chain or branched cyano-C₁₋₆ alkyl, aryl, where the aryl radical can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of halogen, straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, carboxyl, straight-chain or branched C₁₋₈ alkoxycarbonyl, by trifluoromethyl, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, benzyloxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, cyano, straight-chain or branched cyano-C₁₋₆ alkyl, where ft and R₁ or R₂ and R₃ can form a fused aromatic 6-membered ring with the quinoline ring forming an acridine ring which for its part can be substituted a any C atom ring position by the radicals R, R₁, R₂ and R₃ having the meanings mentioned above; P and Q are each 2 hydrogen atoms; Z is oxygen or sulfur, where the radical

substituted on the quinoline heterocycle can be attached to C atoms C₂₋₈ of the quinoline ring skeleton; X is nitrogen; n is 1 or 2 and m is 0 or 1, with the proviso that the sum of n and m is 2; R₄ is C₆₋₁₄ aryl-C₁₋₄ alkyl radical whore the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of C₁₋₆ alkyl, halogen or oxo (═O) and where the C₆₋₁₄ aryl or be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, halogen, cyano, C₁₋₆ alkoxycarbonylamino, carboxyl, C₁₋₈ alkoxycarbonyl, straight-chain or branched C₁₋₆ alkyl which is substituted by one or more fluorine atoms, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, where adjacent oxygen atoms can also be linked by C₁₋₂ alkylene groups, benzyloxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, aryl, which can be unsubstituted or mono- or polysubstituted by identical or different substituents from the group consisting of straight-chain or branched C₁₋₈ alkyl, C₃₋₇ cycloalkyl, carboxyl, straight-chain or branched C₁₋₈ alkoxycarbonyl, trifluoromethyl, hydroxyl, straight-chain or branched C₁₋₈ alkoxy, benzyloxy, nitro, amino, mono-C₁₋₄ alkylamino, di-C₁₋₄ alkylamino, cyano, straight-chain or branched cyano-C₁₋₆ alkyl; and their structural isomers and stereoisomers and their pharmaceutically acceptable salts.
 7. The quinoline derivative of claim 1 or 6, wherein in R, R₁, R₂ and R₃, said C₁₋₈ alkylcarbonyl is acetyl, said C₁₋₈ alkoxy is benzyloxy or phenylethoxy, said fluorine atoms are trifluoromethyl, said C₂₋₆ alkenyl is allyl, said C₂₋₆ alkynyl is ethynyl or propargyl, said cyano-C₁₋₆ alkyl is cyanomethyl, said C₁₋₈ alkoxy-carbonyl is tert-butoxycarbonyl, and said C₁₋₈ alkoxy is methoxy or ethoxy, and in R₄ said fluorine atoms are trifluoromethyl, said C₁₋₈ alkoxy is methoxy or ethoxy, and said C₁₋₂ alkylene group is a methylene group.
 8. The quinoline derivative of claim 1 or 6, wherein R₄ has the meanings given above, R, R₁, R₂, R₃ each is hydrogen, Z is an oxygen atom, X is a nitrogen atom, P and Q are each two hydrogen atoms as in —CH₂—, m is zero, and n is
 2. 9. A process for preparing the quinoline derivative of claim 1 or 6, which comprises reacting a quinoline carboxylic acid of formula (2)

in which R, R₁, R₂, R₃ have the meanings given above, Z is an oxygen or sulfur atom, and Y is a leaving group with an amine of formula (3)

in which R₄, X, P, Q, n and m have the meanings given above, optionally in the presence of diluents and auxiliaries.
 10. A medicament which comprises as active ingredient at least one quinoline derivative according of claim 1 or 6, together with conventional pharmaceutically acceptable auxiliaries, additives and carriers.
 11. The pharmaceutically acceptable acid addition salt of the quinoline derivative of claim 1 or 6, when formed with one of the acids hydrochloric acid, hydrobromic acid, sulfuric acid, phosphoric acid, fumaric acvid, succinic acid, lactic acid, citric acid, acetic acid, tartaric acid, malic acid, maleic acid, embonic acid, malonic acid, trifluoroacetic acid, metanesulfonic acid, and sulfoacetic acid.
 12. The quinoline derivative of formula 1 of claim 6, wherein R, R₁, R₂, R₃, X, Z, P, Q, n and m have the meanings given in claim 6; R₄ is a 2-, 4-, 5- or 6-pyrimidinyl radical, or a 2-, 4-, 5- or 6-pyrimidinyl- C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O) and the 2-, 4-, 5- or 6-pyrimidinyl radical can be unsubstituted or mono- or up to trisubstituted by the same or different substituents from the group of hydrogen, or Y wherein Y is a C₁₋₆ alkyl, halogen, nitro, amino, mono-C₁₋₆ alkylamino, di-C₁₋₆ alkylamino, hydroxyl, C₁₋₆ alkoxy, benzyloxy, carboxyl, C₁₋₆ alkoxycarbonyl, C₁₋₆ alkoxycarbonylamino or C₁₋₆ alkyl which is mono- or polysubstituted by fluorine, C₆₋₁₀ aryl and C₆₋₁₀ aryl-C₁₋₆ alkyl; a 3-, 4-, 5-or 6-pyridazinyl radical, or a 3-, 4-, 5- or 6pyridazinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 3-, 4-, 5- or 6-pyridazinyl radical can be unsubstituted or mono- or up to trisubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 3-, 5- or 6-pyrazinyl radical, or a 2-, 3-, 5-or 6-pyrazinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different Substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 3-, 5- or 6-pyrazinyl radical can be unsubstituted or mono- or up to trisubstituted by the same or different substituents from the group of hydrogen, or Y; a 3-, 4-, 5-, 6-, 7-, or 8-cinnolinyl radical, or a 3-, 4-, 5-, 6-, 7-, or 8-cinnolinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₄ alkyl, halogen or oxo (═O), and the 3-, 4-, 5-, 6-, 7-, or 8-cinnolinyl radical can be unsubstituted or mono- or up to pentasubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 4-, 5-, 6-, 7-, or 8-quinazolinyl radical, or a 2-, 4-, 5-, 6-, 7 or 8-quinazolinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of hydrogen, C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 4-, 5-, 6-, 7-, or 8-quinazolinyl radical can be unsubstituted or mono- or up to pentasubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 3-, 5-, 6-, 7-, or 8-quinoxalinyl radical, or a 2-, 3-, 5-, 6-, 7-, or 8-quinoxalinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 3-, 5-, 6-, 7-, or 8-quinoxalinyl radical can be unsubstituted or mono- or up to pentasubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 4-, 5-, 6-, 7-, or 8-phthalazinyl radical, or a 1-, 4-, 5-, 6-, 7-, or 8-phthalazinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 3-, 4-, 5-, 6-, 7-, or 8-phthalazinyl radical can be unsubstituted or mono- or up to pentasubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolyl radical, or a 2-, 3-, 4-, 5-, 6-, 7 or 8-quinolyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 3-, 4-, 5-, 6-, 7- or 8-quinolyl radical can be unsubstituted or mono- or up to hexasubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolyl radical, or a 1-, 3-, 4-, 5-, 6-, 7- or 8-isoquinolyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 4-, 5-, 6-, 7- or 8-isoquinolyl radical can be unsubstituted or mono- or up to hexasubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 6-, 8- or 9-[9H]-purinyl radical, or a 2-, 6-, 8- or 9-[9H]-purinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 6-, 8- or 9-[9H]-purinyl radical can be unsubstituted or mono- to trisubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 6-, 7- or 8-[7H]-purinyl radical, or a 2-, 6-, 7- or 8-[7H]-purinyl-C₁₋₄ alkyl radical, wherein the C₁₋₄ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 6-, 7- or 8-[7H]-purinyl radical can be unsubstituted or mono- or up to trisubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridinyl radical, or a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridinyl-C₁₋₄ alkyl radical, where the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-acridinyl radical can be unsubstituted or mono- to octasubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-phenanthridinyl radical, or a 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-phenanthridinyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of hydrogen, C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 2-, 3-, 4-, 5-, 6-, 7-, 8- or 9-phenanthridinyl radical can be unsubstituted or mono- or up to octasubstituted by the same or different substituents of Y; a 2-, 3-, 4-, 5- or 6-pyridyl radical where the 2-, 3-, 4-, 5- or 6pyridyl radical can be unsubstituted or mono- or up to tetrasubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 3-, 4-, 5- or 6-pyridinyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 3-, 4-, 5- or 6-pyridinyl radical can be unsubstituted or mono- or up to tetrasubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 3-, 4- or 5-thienyl radical, or a 2-, 3-, 4- or 5-thienyl- C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 3-, 4, or 5-thienyl radical can be unsubstituted or mono- or up to trisubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 4-, or 5-thiazolyl radical, or a 2-, 4-, or 5-thiazolyl C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 4-, or 5-thiazolyl radical can be unsubstituted or mono- or disubstituted by the same or different substituents from the group of hydrogen, or Y; a 3-, 4-, or 5-isothiazolyl radical, or a 3-, 4-, or 5-isothiazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 3-, 4-, or 5-isothiazolyl radical can the unsubstituted or mono- or disubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 4-, 5-, 6-, or 7-benzothiazolyl radical, or a 2-, 4-, 5-, 6-, or 7-benzothiazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 4-, 5-, 6-, or 7-benzothiazolyl radical can be unsubstituted or mono- or up to tetrasubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 2-, 4-, or 5-imidazolyl radical, or a 1-, 2-, 4-, or 5 imidazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 2-, 4-, or 5-imidazolyl radical can be unsubstituted or mono- or up to trisubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 3-, 4-, or 5-pyrazolyl radical, or a 1-, 3-, 4- or 5-pyrazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alky radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 3-, 4- or 5-pyrazolyl radical can be unsubstituted or mono- or up to trisubstituted by the same of different substituents from the group of hydrogen, or Y; a 1-, 2-, 3-, 4-, or 5-pyrrolyl radical, or a 1-, 2-, 3-, 4-, or 5-pyrrolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 2-, 3-, 4- or 5-pyrrolyl radical can be unsubstituted or mono- or up to tetrasubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 3-, or 5-[1.2.4]-triazolyl radical, or a 1-, 3-, or 5-[1.2.4]-triazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of hydrogen, C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 3-, or 5-[1.2.4]-triazolyl radical can be unsubstituted or mono- or disubstituted by the same or different substituents from Y; a 1-, 4-, or 5-[1.2.3]-triazolyl radical, or a 1-, 4-, or 5-[1.2.3]-triazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 4-, or 5-[1.2.3]-triazolyl radical can be unsubstituted or mono- or disubstituted by the same or different substituents from the group of hydrogen, or Y; a 1- or 5-[1H]-tetrazolyl radical, or a 1-, or 5-[1H]-tetrazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alky radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, or 5-[1H]-tetrazolyl radical can be unsubstituted or substituted by hydrogen, or Y; a 2- or 5-[2H]-tetrazolyl radical, or a 2- or 5-[2H]-tetrazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 2- or 5-[2H]-tetrazolyl radical can be unsubstituted or substituted by hydrogen, or Y; a 2-, 4-, or 6-[1.3.5]-triazinyl radical, or a 2-, 4-, or 6-[1.3.5]-triazinyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alkyl radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of hydrogen, C₁₋₆ alkyl, halogen or oxo (═O), and the 2-, 4-, or 6-[1.3.5]-triazinyl radical can be unsubstituted or mono- or disubstituted by the same or different substituents from the group of hydrogen, or Y; a 2-, 4-, or 5-oxazolyl radical, or a 2-, 4-, or 5-oxazolyl-C₁₋₆ alky radical, wherein the C₁₋₆ alky radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alky, halogen or oxo (═O), and the 2-, 4-, or 5-oxazolyl radical can be unsubstituted or mono- or disubstituted by the same or different substituents from the group of hydrogen, or Y; a 3-, 4-, or 5-isoxazolyl radical, or a 3-, 4-, or 5-isoxazolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alky radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 3-, 4-, or 5-isoxazolyl radical can be unsubstituted or mono- or disubstituted by the same or different substituents from the group of hydrogen, or Y; a 1-, 2-, 3-, 4-, 5-, 6- or 7-indolyl radical, or a 1-, 2-, 3-, 4-, 5-, 6 or 7-indolyl-C₁₋₆ alkyl radical, wherein the C₁₋₆ alky radical can be unsubstituted or mono- or polysubstituted by the same or different substituents from the group of C₁₋₆ alkyl, halogen or oxo (═O), and the 1-, 2-, 3-, 4-, 5-, 6- or 7-Indolyl radical can be unsubstituted or mono- or up to hexasubstituted by the same or different substituents from the group of hydrogen, or Y.
 13. The quinoline derivative of claim 2 or 12, wherein in R₄ said fluorine atoms are trifluoromethyl, and said C₁₋₈ alkoxy is methoxy or ethoxy. 